Mendelian randomization analysis – Communicable Diseases Research

A Mendelian randomization study of genetic predisposition to autoimmune diseases and COVID-19

Article

Published on 2022-10-212022-11-16
Journal: Scientific Reports
[Category] 변종,

Noise-augmented directional clustering of genetic association data identifies distinct mechanisms underlying obesity

유전자 연관성 데이터의 소음-증류 방향성 클러스터링

Research Article

Published on 2022-01-272022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] acting applied approach approach association biological pathway biological pathways BMI body mass body mass index can not Cluster Clustering complex Coronary heart disease correlated directional disease Effect elevated estimate generate Genetic genetic association Genetic variant genetic variants Genome-wide association studies group heart disease identify include Inflammation insight mechanism mechanisms Mendelian randomization analyses Mendelian randomization analysis mixture model obesity outliers provide question reduced risk robustness similarity statistical Support thought traits variant variants
[DOI] 10.1371/journal.pgen.1009975 PMC 바로가기 [Article Type] Research Article

Leveraging Genetic Data to Elucidate the Relationship Between COVID‐19 and Ischemic Stroke

유전 데이터를 활용하여 COVID-19와 허혈성 뇌졸중 사이의 관계 설명

Original Research

Published on 2021-11-102022-09-10
Journal: Journal of the American Heart Association
[Category] MERS, 변종,

[키워드] 95% CI Analysis associations body mass body mass index C‐reactive protein cardiovascular disease chronic inflammation correlation COVID‐19 COVID‐19 Critical cross‐trait linkage disequilibrium score regression death defined Epidemiology estimate Evidence evidence of false discovery rate Genetic genetic data genetics Hospitalization host response Inclusion increase in increased risk increased the risk independent independent of investigated Ischemic Ischemic Stroke Linkage disequilibrium mendelian randomization Mendelian randomization analysis multivariable Odds ratio outcome outcomes P ‐value pleiotropic predicted relationship reported respiratory Respiratory Support Result resulting risk risk factor Risk factors robust sensitivity analysis smoking statistical statistical sensitivity stroke Subtypes Support These data variants was performed was used
[DOI] 10.1161/JAHA.121.022433 PMC 바로가기 [Article Type] Original Research

Mapping the human genetic architecture of COVID-19

COVID-19의 인간 유전 구조 매핑

Meta-Analysis

Published on 2021-07-082022-09-10
Journal: Nature
[Category] Fulltext, SARS, 신약개발, 유전자 메커니즘, 임상, 진단, 치료법,

[키워드] association Autoimmune autoimmune and inflammatory diseases body-mass body-mass index causal relationship causal relationships chance Community complex human disease contribute COVID-19 COVID-19 severity diabetes environmental risk factor exposure to Factor Genetic genetic architecture genetic factors genetics genome-wide association Genome-wide association studies genome-wide significant Host host genetics Human genetics identifying individual Infection inflammatory disease Inflammatory diseases International loci lung manifestation mapping mechanism Mendelian randomization analyses Mendelian randomization analysis meta-analysis outcomes Pandemics patients with COVID-19 researcher resource SARS-CoV-2 SARS-COV-2 infection severe COVID-19 severe manifestations of COVID-19 severity of COVID-19 smoking Support susceptibility therapeutic Type II Diabetes Viral viral infection with COVID-19 working model
[DOI] 10.1038/s41586-021-03767-x PMC 바로가기 [Article Type] Meta-Analysis

Coagulation factors and the incidence of COVID-19 severity: Mendelian randomization analyses and supporting evidence

Letter

Published on 2021-06-072022-10-04
Journal: Signal Transduction and Targeted Therapy
[Category] MERS, SARS, 유전자 메커니즘,

[키워드] coagulation factor Evidence Genetics research Genome informatics incidence of COVID-19 Mendelian randomization analysis Predictive markers
[DOI] 10.1038/s41392-021-00640-1 PMC 바로가기 [Article Type] Letter

Liver and Kidney Function Biomarkers, Blood Cell Traits and Risk of Severe COVID-19: A Mendelian Randomization Study

Genetics

Published on 2021-05-272022-10-31
Journal: Frontiers in Genetics
[Category] COVID-19,

Alcohol Consumption Is Associated with Poor Prognosis in Obese Patients with COVID-19: A Mendelian Randomization Study Using UK Biobank

알코올 소비는 COVID-19에 걸린 비만 환자의 나쁜 예후와 관련이 있습니다: UK Biobank를 사용한 멘델식 무작위 배정 연구

Clinical Trial

Published on 2021-05-102022-08-13
Journal: Nutrients
[Category] SARS, 변종, 임상,

[키워드] 95% CI Acute and chronic alcohol abuse acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Adaptive immune response ADH1B adverse effect adverse effects adverse impact alcohol Alcohol Abuse alcohol consumption Alcohol Dehydrogenase allele Analysis applied association average carrier Clinical outcome conducted Consumption coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 COVID-19 patients death death in COVID-19 dehydrogenase Evidence family GCKR Genetic variant glucokinase heavy drinking higher risk Infection instrumental variable instrumental variables Logistic regression member mendelian randomization Mendelian randomization analyses Mendelian randomization analysis Mortality obesity outcome outcomes participant Participants Patient patients patients with COVID-19 patients with obesity Poor positive progression promote reduced regulator respiratory risk risk of death SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 positivity Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 SLC39A8 Solute susceptibility tested UK biobank
[DOI] 10.3390/nu13051592 PMC 바로가기 [Article Type] Clinical Trial

Cardiometabolic risk factors for COVID-19 susceptibility and severity: A Mendelian randomization analysis

COVID-19 감수성 및 중증도에 대한 심혈관 대사 위험 요소: 멘델식 무작위 분석

Research Article

Published on 2021-03-042022-08-13
Journal: PLoS Medicine
[Category] meta-analysis, SARS, 변종, 유전자 메커니즘, 진단, 치료제,

[키워드] Aaron amplified amplify analyses Analysis association associations average BMI body mass body mass index calculated cardiometabolic cardiometabolic condition cardiometabolic conditions cardiometabolic consequence cardiometabolic disease cardiometabolic diseases cardiometabolic exposure cardiometabolic risk factor Cardiometabolic risk factors cardiometabolic trait cardiometabolic traits causal relationship Causality Chronic kidney disease cohorts Conditioning Control controls Coronary artery Coronary artery disease Coronary heart disease correlated COVID-10 COVID-19 COVID-19 disease COVID-19 hospitalization COVID-19 Host Genetics Initiative GWAS meta-analyses COVID-19 illness COVID-19 pandemic COVID-19 severity COVID-19 susceptibility defined described diabetes Effect estimate European evaluate Evidence General population Genetic genetic evidence genetic instrument Genetic variant genetic variants Genome-wide association studies Genome-wide association study GWAS meta-analysis GWASs higher risk hospital Hospitalization hospitalized COVID-19 indirect effect indirect effects individual initiative Intervention Kidney disease mediators mendelian randomization Mendelian randomization analyses Mendelian randomization analysis obesity Obesity-related cardiometabolic diseases Odds ratio on type outcome outcomes p < 0.05/34 tests pairwise multivariable MR performed Pleiotropy population-based cohort population-based cohorts positive raise raising reduce repeated researcher risk risk factor Risk factors risk of COVID-19 selected severe COVID-19 severity statistical significance statistically significant stroke Support susceptibility tested traits type 2 diabetes UK biobank with COVID-19
[DOI] 10.1371/journal.pmed.1003553 PMC 바로가기 [Article Type] Research Article

Association of serum HDL-cholesterol and apolipoprotein A1 levels with risk of severe SARS-CoV-2 infection

심각한 SARS-CoV-2 감염 위험과 혈청 HDL-콜레스테롤 및 아포지단백 A1 수치의 연관성

Multicenter Study

Published on 2021-03-022022-09-10
Journal: Journal of Lipid Research
[Category] 바이오마커, 변종,

[키워드] 95% CI, 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age allele alleles ApoA1, apolipoprotein A1 APOE4 apolipoprotein A1 association Biomarker CAD, coronary artery disease cholesterol clinical risk factor Clinical risk factors Coronary artery Coronary artery disease coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection COVID-19, Coronavirus disease 2019 cumulative cumulative effects diabetes Effect elevated evaluated Evidence feature genetic risk score Genetic variant genetic variants GRS, genetic risk scores HDL-cholesterol higher risk homozygous hypertension ICD-10, International Classification of Diseases, Tenth Revision increase in individual Infection investigated Logistic regression analyses Logistic regression analysis mendelian randomization Mendelian randomization analyses Mendelian randomization analysis metabolic syndrome Mortality MR, Mendelian randomization MVMR, multivariate MR negative controls Novel coronavirus obesity OR, odds ratio outcomes PC, principal component reduced risk respiratory Respiratory disease risk SAR-CoV-2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 serum serum biomarker serum biomarkers severe acute respiratory syndrome Coronavirus Severe COVID-19 Infection severe respiratory disease severe SARS-CoV-2 severity of COVID-19 Sex susceptible syndrome type 2 diabetes UK biobank were used
[DOI] 10.1016/j.jlr.2021.100061 PMC 바로가기 [Article Type] Multicenter Study